In vitro fertilization is one of the assisted reproductive methods applied to couples who cannot achieve pregnancy for any reason.
For this purpose, after ovarian stimulation with appropriate drugs from the woman, the eggs obtained by egg collection are combined with the sperm produced by the man by microinjection (ICSI) method. Then, the division of the fertilized eggs, that is, the stages of their transformation into embryos, are followed and their transfer into the uterus is planned with the appropriate timing according to the planned treatment type.
Who is recommended IVF Treatment?
In vitro fertilization treatment is preferred in cases where there is a situation that prevents spontaneous conception due to factors belonging to the woman or man, and where pre-in vitro fertilization treatment options are not successful or these methods will not yield results. You can find more detailed information on this subject in my article named ‘ Evaluation of Infertile Couple ‘.
In addition, preimplantation genetic diagnosis (PGT-M) in the presence of a known genetic disease in the family, for embryo freezing within the scope of reproductive protection approaches, even though there is no problem in conceiving, or preimplantation genetic screening (PGT-SR) in case of chromosomal problems, in vitro fertilization treatment. applicable.
I can’t conceive. What should I do?
If there is no known condition that will prevent pregnancy, if your age is under 35, if you are not able to conceive despite regular sexual intercourse for 1 year, if over 35, for 6 months, you should consult a physician who is concerned with reproduction. In the first step evaluation, anatomical evaluation including the vagina, uterus and ovaries in women, determination of ovarian reserve and determination of ovulation status, and sperm analysis in men will be appropriate. If the woman’s age is over 40, I recommend applying for evaluation without delaying beyond a few months.
How to Start IVF Treatment and How Long Does It Take?
First of all, we would like to see the couple who are having trouble conceiving to evaluate. In this assessment, we take detailed stories from men and women about issues that may be related to reproduction. Then, with the pelvic examination and ultrasonography performed on the woman, we are sure whether there is an anatomical problem related to the uterus and ovaries and we determine the level of the ovarian reserve. We can determine whether there is a problem with the sperm analysis performed on the man.
Then, we determine the personalized treatment protocol according to the individual characteristics, age and ovarian reserve of each couple. Because the chance of success is higher with individualized treatment. Although IVF treatment is started with the woman’s menstrual day, sometimes, according to the selected drug protocol, it may be necessary to use some drugs before menstruation. For this reason, we recommend that couples be evaluated one or two months before the treatment is considered, without a specific timing regarding menstruation. Thus, the necessity of examination that may be required before the treatment can be reviewed, and the type of drug treatment to be used in IVF can be decided.
In vitro fertilization treatment takes approximately 2-2.5 weeks from menstruation. You can find detailed information about IVF treatment steps in my articles ‘Ovaries Stimulation’, ‘Egg Collection’, ‘Fertilization of Eggs-Microinjection’ and ‘Embryo Transfer’. Pregnancy status can also be understood with a blood pregnancy test performed 2 weeks after the egg retrieval day.
Why is the chance of success in IVF is not the same for every couple?
The chance of success in IVF treatment varies according to the individual characteristics of the couple. in this context;
- One of the most important factors is the age of the woman. If the woman’s age is 38, especially over 40, the probability of the eggs produced to be chromosomally problematic, that is, unhealthy, increases, which reduces the possibility of pregnancy and live birth, and increases the risk of having unhealthy children.
- Ovarian reserve; If the number of eggs in the ovaries, that is, the ovarian reserve is good, the number of embryos to be obtained will also increase, and in addition to the transferred embryo, the probability of obtaining embryos of quality to be frozen will increase. At the same time, the increase in the possibility of transferring embryos at the blastocyst stage, that is, on the 5th day, will increase the pregnancy rates.
- Embryo transfer day ; The fact that embryo transfer is performed at the blastocyst stage, that is, on the 5th day, increases the chance of pregnancy even more compared to the 3rd day, that is, the cleavage stage. Because with embryo transfer at the blastocyst stage, we can select the embryo with a higher probability of attachment to the uterus with higher accuracy.
- Factors with negative effects ; In case of recurrent IVF failure in the presence of obstruction in the tubes and the presence of a fluid-filled tube (hydrosalpenx), the thinness of the inner wall of the uterus, adhesions in the uterus or the presence of myoma uteri pressing into the uterus, pregnancy results will be adversely affected after IVF treatment.
After the follow-up, when the egg sacs reach the desired size, we plan the egg collection process 34-36 hours after the cracking needle. In general, we prefer to make cracking needles when at least 3 follicles exceed 17 mm in size in our applications. The purpose of applying the cracking needle is not to crack the eggs, but to ensure their final maturation.